Methods of inhibiting the binding of a CD8+ T cell to a class I MHC employing a modified beta 2 microglobulin

摘要

The present invention provides a method of inhibiting the binding of a CD8+ T cell to a class I Major Histocompatibility Complex (MHC). The method comprises exposing the class I MHC to a modified beta2-microglobulin whose binding to CD8 is inhibited. Also provided are modified beta2-microglobulin molecules and nucleic acids encoding such molecules.