METHOD OF PRODUCING N-[(2S)-SULFANYL-4-(1,5,5-TRIMETHYLHYDANTOINYL)BUTANOYL]-L-LEUCYL-L-TERT-LEUCINE N-METHYLAMIDE AND INTERMEDIATE THEREOF

摘要

Process for producing N-[(2S)-sulfanyl-4-(1,5,5-trimethylhydantoinyl)butanoyl]-L-leucyl-L-te rt-leucine N-methylamide by forming an intermediate compound N-[(2S)-thiobenzoyl-4-(1,5,5-trimethylhydantoinyl)butanoyl]-L-leucyl-L -tert-leucine N-methylamide by an improved process that substantially reduces the presence of contaminants in the reaction mixture.