| 摘要 |
<p>Software methods for identifying associations between genetic information an d particular genetic traits are described. A candidate single nucleotide polymorphism (SNP) combination is selected from a plurality of candidate SNP combinations for a gene associated with (or suspected to be associated with) a genetic trait. Haplotype data associated with this candidate SNP combination are read for a plurality of individuals and grouped into a positive-respondi ng group and a negative-responding group based on whether a predetermined trait criteria for an individual is met. A statistical analysis on the grouped haplotype data is performed to obtain a statistical measurement associated with the candidate SNP combination. The acts of selecting, reading, grouping , and performing are repeated as necessary to identify the candidate SNP combination having the optimal statistical measurement (if one exists). In o ne approach, all possible SNP combinations are selected and statistically analyzed. In another approach, a directed search based on results of previou s statistical analysis of SNP combinations is performed until the optimal statistical measurement is obtained. In addition, the number of SNP combinations selected and analyzed may be reduced based on a simultaneous testing procedure.</p> |
