PREPARATION OF TRANS-FUSED 3,3A,8,12B-TETRAHYDRO-2PREPARATION OF TRANS-FUSED 3,3A,8,12B-TETRAHYDRO-2PREPARATION OF TRANS-FUSED 3,3A,8,12B-TETRAHYDRO-2H-DIBENZO[3,4:6,7]CYCLOHEPTA[1,2-B]FURAN DERIVATIVH-DIBENZOÝ3,4:6,7¨CYCLOHEPTAÝ1,2-B¨FURAN DERIVATIVH-DIBENZOÝ3,4:6,7¨CYCLOHEPTAÝ1,2-B¨FURAN DERIVATIVES ES ES

摘要

The present invention concerns processes for the preparation of each of the 4 diastereomers of formula (I): in stereochemically pure form from either of t wo enantiomerically pure precursors. The tetracyclic ringsystem having trans- fused five and seven membered rings is formed in an acid-catalysed cyclizati on reaction. The invention further relates to the thus obtained cis-fused tetracyclic alcohol intermediates, the methanamine end-products, the methanamine end-products for use as a medicine, in particular as CNS active medicines.