发明名称 |
Apoptosis-inducing single-chain Fv |
摘要 |
This invention relates to Novel single-chain Fvs capable of inducing apoptosis of nucleated blood cells having Integrin Associated Protein (IAP). The single-chain Fvs of the invention comprise an L chain comprising the L chain V region of the mouse monoclonal antibodies capable of inducing apoptosis of cells having human IAP, an H chain comprising the H chain V region of the mouse monoclonal antibodies capable of inducing apoptosis of cells having human IAP and a linker connecting them. The single-chain Fvs of the invention are useful as a therapeutic agent for blood dyscrasia such as leukemia.
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申请公布号 |
US2003108546(A1) |
申请公布日期 |
2003.06.12 |
申请号 |
US20020138505 |
申请日期 |
2002.05.06 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
FUKUSHIMA NAOSHI;UNO SHINSUKE;OH-EDA MASAYOSHI;KIKUCHI YASUFUMI |
分类号 |
A61K38/00;A61P7/00;C07K16/18;C07K16/28;C07K16/30;C12N1/21;C12N15/12;(IPC1-7):A61K39/395 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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