发明名称 |
SITE-SPECIFIC, ANTIBODY-MEDIATED ACTIVATION OF PROAPOPTOTIC CYTOKINE: AMAICE (ANTIBODY-MEDIATED APOPTOSIS INDUCING CYTOKINE) |
摘要 |
<p>Subject matter of the invention are antibody-cytokine fusion proteins having proapoptotic and immune modulating properties, but wherein the cytokine moiety a priori has a bioactivity which is very low or restricted to certain receptor subtypes. These reagent exert their full biological activity via the corresponding cytokine receptor(s) only after antibody-mediated binding of the fusion protein to a specific cell membrane-expressed target molecule. By suitable choice of the antibody specificity, the cytokine activity is directed to the tissue, e.g. tumour tissue, to be treated, and a therapeutic agent can be produced being specifically designed/optimised for the respective indication/tumour entity.</p> |
申请公布号 |
EP1317488(A2) |
申请公布日期 |
2003.06.11 |
申请号 |
EP20010984646 |
申请日期 |
2001.09.07 |
申请人 |
PFIZENMAIER, KLAUS;WAJANT, HARALD |
发明人 |
PFIZENMAIER, KLAUS;WAJANT, HARALD;MOOSMAYER, DIETER;WUEEST, THOMAS |
分类号 |
C07K14/525;C12N15/09;A61K35/12;A61K35/76;A61K38/00;A61K39/395;A61K47/48;A61K48/00;A61P3/00;A61P19/02;A61P29/00;A61P31/04;A61P35/00;A61P37/06;C07K14/52;C07K14/705;C07K16/18;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12P21/02;(IPC1-7):C07K14/47 |
主分类号 |
C07K14/525 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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