| 摘要 |
A novel phosphine compound having excellent properties (chemical selectivity, enantioselectivity, catalytic activity) as a catalyst for asymmetric syntheses, especially asymmetric hydrogenation. A phosphine-phospholane compound represented by the following general formula: <CHEM> wherein R<1> represents hydrogen atom, a linear or branched alkyl group having 1 to 4 carbon atoms; R<2> represents hydrogen atom, or OR<21>, R<21> represents an alkyl group having 1 to 4 carbon atoms, a represents an integer of 1 to 2, b represents an integer of 1 to 3, sum of a and b represents an integer of 2 to 3, provided that at least one of R<1> and R<2> is not hydrogen atoms; R<3>, R<4>, R<5> and R<6> are the same or different, and each represents hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or an alkoxy group having 1 to 6 carbon atoms, and R<3> and R<4>, R<4> and R<5>, and/or R<5> and R<6> may be combined to form a ring which may contain at least one oxygen atoms; and R<7> and R<8> are the same or different, and each represents a linear or branched alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 7 carbon atoms, a perfluoroalkyl group, a phenyl group, a phenyl group having at least one substituents each selected from the group consisting of an alkyl group having 1 to 6 carbon atoms, an alkyl group having 1 to 6 carbon atoms which is substituted by one or more halogen atoms, an alkoxy group having 1 to 6 carbon atoms, and a halogen atom, an aralkyl group having 7 to 12 carbon atoms, or a ring-substituted aralkyl group.)
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