发明名称 |
New 4-demethoxy-4-amino-anthracycline glycoside derivs. - useful as antitumour agents and new aglycone intermediates |
摘要 |
<p>Anthracycline glycosides of formula (I) and their pharmaceutically acceptable acid addn. salts are new where R1 = H or OH; one of R2 and R3 = H, the other is H or OH. Also new are the intermediates 4-demethoxy-4-amino -7-deoxy-daunomycinone (IX) and daunomycinones (II), opt. N-protected. (I) is pref. 4-demethoxy-4 -amino-daunorubicin; 4-demethoxy- 4-amino-4'-epi-daunorubicin or 4-demethoxy-4-amino -4'-deoxy-daunorubicin, and the corresp. doxorubicin cpds.</p> |
申请公布号 |
DK174561(B1) |
申请公布日期 |
2003.06.10 |
申请号 |
DK19940001046 |
申请日期 |
1994.09.12 |
申请人 |
PHARMACIA ITALIA S.P.A. |
发明人 |
ARCAMONE, FEDERICO;CARUSO, MICHELE;SUARATO, ANTONINO;ANGELUCCI, FRANCESCO |
分类号 |
C07C50/38;(IPC1-7):C07C50/38 |
主分类号 |
C07C50/38 |
代理机构 |
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代理人 |
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地址 |
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