PROCESS FOR THE PREPARATION OF SUSTAINED RELEASE PELLETS

摘要

A process for the manufacture of sustained release pellets comprising pelletizing a mixture containing the drug in finely di- vided form and a binder. The characteristic feature is that: (a) said binder is in particle form consisting of one ar more water-in- soluble wax-like binder substance(s) with a melting point above 40 .degree.C , and (b) said pelletization step is performed by mechanical- ly working said mixture, in a high shear mixer, under the input of a sufficient amount of energy for the binder to melt and pelletization to take place.