WATER-SOLUBLE COMPOSITION FOR SUSTAINED-RELEASE

摘要

A water-soluble composition which comprises (a) a pharmacologically active polypeptide, except erythropoietin, secreted by an animal body or its derivative or a chemically synthesized pharmacologically active substance, (b) a water-soluble species of hyaluronic acid or its nontoxic salt and (c) a water-soluble protein injectable into body fluids without showing any substantial pharmacological activity brings about a prolonged action in vivo of a pharmacologically active substance. In addition, the composition can be administered using a small-gauge needle and thereby contributes to relieving pain in patients.