发明名称 |
T-CELL EPITODES IN CARBOXYPEPTIDASE G2 |
摘要 |
The invention in particular relates to the modification of a bacterial enzyme carboxypeptidease G2 (CPG2) to result in CPG2 proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo. The present invention relates also to T-cell epitope peptides derived from said non-modified protein by means of which it is possible to create modified CPG2 variants with reduced immunogenicity. These polypeptides are suitable particularly for therapeutic use in humans. |
申请公布号 |
AU2002352162(A1) |
申请公布日期 |
2003.06.10 |
申请号 |
AU20020352162 |
申请日期 |
2002.11.27 |
申请人 |
MERCK PATENT GMBH |
发明人 |
KOEN HELLENDOORN;MATTHEW BAKER;STEVEN WILLIAMS;FRANCIS, J. CARR |
分类号 |
C12N15/09;A61K38/00;A61K38/46;A61K38/48;A61K39/00;A61K47/42;A61P43/00;C07K7/08;C12N9/48;C12N9/52;C12N15/57 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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