MANIPULATION OF CYTOKINE LEVELS USING CD83 GENE PRODUCTS
摘要
The invention provides methods for modulating cytokine levels, GM-CSF levels and the immune system using CD83 nucleic acids, CD83 polypeptides, anti-CD83 antibodies and factors that influence CD83 activity or expression. The invention also provides mice having a mutant CD83 gene and mice having a transgenic CD83 gene, which are useful for defining the role of CD83 in the immune system and for identifying compounds that can modulate CD83 and the immune system.
申请公布号
AU2002357759(A1)
申请公布日期
2003.06.10
申请号
AU20020357759
申请日期
2002.11.21
申请人
RAMSDELL, FRED;PROLL, SEAN, C.;STAEHLING-HAMPTON, KAREN;APPELBY, MARK, W.;MARTINEZ, LEON, FERNANDO, GARCIA;CELLTECH R AND D, INC.
发明人
FRED RAMSDELL;SEAN, C. PROLL;KAREN STAEHLING-HAMPTON;MARK, W. APPELBY;LEON, FERNANDO, GARCIA MARTINEZ