| 摘要 |
<p>The invention concerns an improved multiparticulate tablet disintegrating in the mouth in contact with saliva in less than 40 seconds. The invention is characterised in that it is based on particles of coated active principle, said particles having intrinsic compression properties and a mixture of carriers, the proportion of carrier mixture relative to coated active principle particles being 0.4 to 6 parts by weight, the carrier mixture comprising: a disintegrating agent; a diluting soluble agent with binding properties; a lubricant; a permeabilizing agent; and advantageously lubricants, sweeteners, flavouring and colouring agents, the proportion of disintegrating agent and soluble agent relative to the tablet mass being 1 to 15 wt.% for the former and 30 to 90 wt.% for the latter.</p> |
