发明名称 |
Anaerobe targeted enzyme-mediated prodrug therapy |
摘要 |
Recombinant anaerobic bacterial compositions that under anaerobic conditions present in a solid tumor and produce an enzyme capable of catalyzing the conversion of a prodrug to its cytotoxic product in situ are described. Methods of treating tumors using the composition are also described. |
申请公布号 |
US2003103952(A1) |
申请公布日期 |
2003.06.05 |
申请号 |
US20020158976 |
申请日期 |
2002.05.31 |
申请人 |
BROWN JOHN M.;LIU SHIE-CHAU;GIACCIA AMATO J.;MINTON NIGEL P. |
发明人 |
BROWN JOHN M.;LIU SHIE-CHAU;GIACCIA AMATO J.;MINTON NIGEL P. |
分类号 |
A61K35/74;A61K48/00;C12N1/20;C12N1/21;C12N9/02;C12N15/74;(IPC1-7):A61K45/00 |
主分类号 |
A61K35/74 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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