REGULATION OF HYPOXIA-INDUCIBLE GENE EXPRESSION WITH ANTISENSE INHIBITORY PAS DOMAIN PROTEIN

摘要

A pharmaceutical composition comprises the sequence of SEQ ID NO:s 3-5 or pharmaceutically equivalent sequences. Methods employing the pharmaceutical compositions include treatments to increase angiogenesis, to stimulate HIF-1&agr; function, to treat hypoxia-related conditions, and to maintain normal cell functions under hypoxia.