发明名称 |
Identification of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, DNA and viruses |
摘要 |
The present invention relates to internalizing peptides which facilitate the uptake and transport of cargo into the cytoplasm and nuclei of cells as well as methods for the identification of such peptides. The internalizing peptides of the present invention are selected for their ability to efficiently internalize cargo into a wide variety of cell types both in vivo and in vitro. The method for identification of the internalizing peptides of the present invention comprises incubating a target cell with a peptide display library, isolating peptides with internalization characteristics and determining the ability of said peptide to internalize cargo into a cell.
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申请公布号 |
US2003104622(A1) |
申请公布日期 |
2003.06.05 |
申请号 |
US20020075869 |
申请日期 |
2002.02.13 |
申请人 |
ROBBINS PAUL D.;MI ZHIBAO;FRIZZELL RAYMOND;GLORIOSO JOSEPH C.;GAMBOTTO ANDREA |
发明人 |
ROBBINS PAUL D.;MI ZHIBAO;FRIZZELL RAYMOND;GLORIOSO JOSEPH C.;GAMBOTTO ANDREA |
分类号 |
A61K38/00;A61K39/00;A61K47/48;C07K7/06;C07K7/08;C12N15/10;C40B40/02;G01N33/68;(IPC1-7):A61K38/08;A61K38/10;C12N15/85 |
主分类号 |
A61K38/00 |
代理机构 |
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地址 |
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