| 摘要 |
The present invention relates to the use of compounds of the general Formula (I) for the regulation of the quorum sensing system of microorganisms wherein in Formula (I), R is H, alkyl, cycloalkyl, aryl or heteroaryl; R1 is H, alkyl, cycloalkyl, aryl or heteroaryl; R2 is H, alkyl, cycloalkyl, aryl or heteroaryl; A1 and A2 each independently represent an optionally substituted C1-C20-alkyl group which may contain one or more group(s) Z, or a mono cyclic or polycyclic optionally substituted aromatic or non-aromatic ring system which may contain one or more group(s) X, and in case of a polycyclic ring system, said system contains at least one aromatic ring; Z is selected from the group consisting of S, O, N, NR4, CO, CO2, CS, SO or SO2 X is selected from the group consisting of S, O, N, NR4, SO or SO2; said substituted ring system carries a substituent R3 on one or more of the carbon atoms of said ring system; said substituted C1-C20-alkyl group carries a substituent R3 on one or more of the carbon atoms of said alkyl group; R3 is independently H, OR4, SR4, hydroxyalkyl, hydroxyalkylamino, cycloalkyl, halogen, haloalkyl, haloalkyloxy, NO2, CN, SO2NR4R5, CO2NR4R5, COR4, CO2R4, SO2R4, SO3R4, NR4R5, alkyl, aryl or heteroaryl; R4 is H, alkyl, cycloalkyl, aryl or heteroaryl; R5 is H, O-alkyl, O-aryl, alkyl, heteroaryl or aryl; Y1 and Y2 are independent from each other C=O, C=S, SO2 or C=NR5; p is 0, m is 0, n is 0; or p is 0, m is 1, n is 1; or p is 1, m is 0, n is 1; or p is 0, m is 0, n is 1; or p is 1, m is 0, n is 0; or p is 1, m is 1, n is 1.
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