PHARMACEUTICAL COMPOSITION WITH COMBINED ACTIVE AGENTS CONTAINING METFORMIN AND A HYDROXYLAMINE DERIVATIVE

摘要

The invention relates to a pharmaceutical composition containing a combination of metformin and a hydroxylamine derivative as active agent. The composition of the invention can be used in the therapy of the diabetes mellitus, especially in the therapy of type II (non-insulin dependent, NIDDM) diabetes mellitus. The hydroxylamine derivative is a compound of general formula (I), wherein Ar is pyridyl, thienyl, phenyl, halophenyl or nitrophenyl group, X is halo, n has the value of zero or 1, Z is a methylene group, oxygen or an Alk-N= group wherein Alk represents a C>1-4< alkyl group, Y is hydrogen or hydroxy, or an acid addition salt thereof.