BENZAMIDE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND THEIR PHARMACEUTICAL USE

摘要

The present invention relates to novel hydroxyethylene compounds having Asp2 (&bgr;−secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated &bgr; − amyloid levels or &bgr;−amyloid deposits, particularly Alzheimer's disease.