HYDRAZONOPYRAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTICS

摘要

Pharmaceutical compositions and compounds are provided. The compounds of the invention deomonstrate anti-proliferative activity, and may promote apoptosi s in cells lacking normal regulation of cell cycle and death. In one embodimen t of the invention, pharmaceutical compositions of the compounds in combinatio n with a physiologically acceptable carrier are provided. The pharmaceutical compositions are useful in the treatment of hyperproliferative disorders, which disorders include tumor growth, Iymphoproliferative diseases, angiogenesis. The compounds of the invention are substituted pyrazoles and pyrazolines.