Single isomer methylphenidate and resolution process

摘要

Single isomer methylphenidate, selected from the d-threo and l-threo-enantiomers, has been obtained in purified form, to the extent of less than 2% by weight of a contaminant selected from resolving agent and ritalinic acid. This is achieved by resolution of a mixture of enantiomers using an O,O'-diaroyltartaric acid as resolving agent.