| 发明名称 |
METHOD OF INACTIVATION OF RAS SUBFAMILY PROTEINS AND AGENTS THEREFOR |
| 摘要 |
The invention comprises a method of treating a patient with a disorder, characterized by an activating mutation in the Ras proto-oncogene, comprising contacting cells of said patient with a protein having the toxic activity of Clostridium sordellii toxin LT under conditions favoring inactivating of Ras by glucosylation of Ras' threonine 35 in said cell. Said protein preferably is an immunotoxin which contains as a toxic domain the catalytic domain of toxin LT.
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| 申请公布号 |
US2003103987(A1) |
申请公布日期 |
2003.06.05 |
| 申请号 |
US19980126816 |
申请日期 |
1998.07.31 |
| 申请人 |
VON EICHEL-STREIBER CHRISTOPH;BOQUET PATRICE;THELESTAM MONICA |
发明人 |
VON EICHEL-STREIBER CHRISTOPH;BOQUET PATRICE;THELESTAM MONICA |
| 分类号 |
A61K38/45;A61K47/48;A61K48/00;C07K16/46;C07K19/00;C12N9/10;(IPC1-7):A61K38/00;A61K39/40;A61K39/395;A01N37/18;A61K39/42;A61K39/44;A61K31/545;C07K7/00;C07K14/00;C07K16/00;C12P21/08 |
主分类号 |
A61K38/45 |
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