METHOD FOR PREPARING AND USING POLYOXYETHYLATED CASTOR OIL IN PHARMACEUTICAL COMPOSITIONS

摘要

A method is provided for preparing a pharmaceutical composition comprising: taking polyoxyethylated castor oil which if diluted 1:10 in water has a pH greater than 5 and aging the polyoxyethylated castor oil by exposing the polyoxyethylated castor oil to a gas comprising oxygen for a period of time, the exposure to the gas over the period of time causing an acidity of the polyoxyethylated castor oil to increase; and forming a pharmaceutical composition comprising the aged polyoxyethylated castor oil and a pharmaceutically active agent such as paclitaxel; wherein at least 80% of th e potency of the pharmaceutically active agent is retained by the pharmaceutic al composition after the pharmaceutical composition is stored for at least 7 da ys at 40~C.