发明名称 |
Screening assay for the identification of inhibitors of macrophage migration inhibitory factor |
摘要 |
The present invention encompasses assays to identify compounds that inhibit the enzymatic activity of MIF which catalyzes the tautomerization of MIF-substrates, such as D-dopachrome to DHICA. In general, the assay is conducted in vitro by adding, mixing or combining MIF and a suitable substrate in the presence or absence of a test compound, and measuring the tautomerization of the substrate. The test compounds that inhibit tautomerization in the assay are identified as MIF inhibitors.
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申请公布号 |
US2003105014(A1) |
申请公布日期 |
2003.06.05 |
申请号 |
US20020226299 |
申请日期 |
2002.08.23 |
申请人 |
BUCALA RICHARD;ULRICH PETER C.;XHANG XINI;CERAMI ANTHONY |
发明人 |
BUCALA RICHARD;ULRICH PETER C.;XHANG XINI;CERAMI ANTHONY |
分类号 |
A61K31/122;A61K31/167;A61K31/404;A61K38/00;C07K14/52;(IPC1-7):A61K31/00;A61K38/17;C12Q1/26 |
主分类号 |
A61K31/122 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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