METHODS FOR INHIBITING DEACETYLASE ACTIVITY

摘要

A method for identifying a compound that inhibits the NAD+−dependent deacetylase activity of a SIR2 protein is disclosed. These compounds are useful for the treatment of cancers and other diseases, through the activation of silenced genes, through the promotion of apoptosis in cancerous cells, and through the inhibition of transcriptional repressor activity in oncogenes.