| 摘要 |
Microcompetition for GABP between a foreign polynucleotide and cellular GABP regulated genes is a risk factor associated with many chronic diseases such as obesity, cancer, atherosclerosis, stroke, osteoarthritis, diabetes, asthma, and other autoimmune diseases. The invention uses this novel discovery to present assays for the diagnosis of these chronic diseases. The assays are based on measuring the cellular copy number of the foreign polynucleotide, measuring the rate of complex formation between GABP and either the foreign polynucleotide, or a cellular GABP regulated gene, identifying modified expression of a cellular GABP regulated gene, or identifying modified activity of the gene product of a GABP regulated gene. The invention also presents other foreign polynucleotide-type assays.
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