USE OF L ISOMERS OF AMINO ACID DERIVATIVES OF HYDROXYGUANIDINE FOR PRODUCING NO, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND PHARMACEUTICAL USES

摘要

The invention concerns synthesis organic chemistry applied in pharmaceutics and concerns the use of the L isomer of a compound of general formula (I), wherein: m is an integer ranging between 0 and 4 (inclusively) for locally producing, in situ and in vivo in the tunicae of human or animal blood vessels, nitrogen monoxide (NO) in the form of NO+ (nitrosonium ion), NO- (nitroxyle ion) or NO DEG (free radical NO), a nitrogen monoxide precursor or a derivative resulting from the interaction of said nitrogen monoxide with its biological targets. The invention is particularly useful for obtaining novel medicines, in particular for obtaining a medicine for preventing or treating deficiency, lesion or absence of vascular endothelium.