Composition for the treatment of ischemic stroke containing zonampanel and a tissue plasminogen activator

摘要

The present invention relates to a combination of Ä7-(1H-imidazol-1-yl)-6-nitro-2, 3-dioxo-3, 4-dihydroquinoxalin-1(2H)-ylÜacetic acid or a salt or hydrate thereof or, preferably, zonampanel together with a tissue plasminogen activator for the therapy of ischemic stroke or for the improvement of neurological symptom accompanied by cerebral infarction, to a method of administration thereof and to a method of therapy therefor. The combination of the present invention showed better effect of reducing the infarct volume than administration of a single component. Therefore, the combination of the present invention is useful as a therapy for ischemic stroke.