| 发明名称 |
HERPES SIMPLEX VIRUS-1 DELETION VARIANTS AND VACCINES THEREOF |
| 摘要 |
<p>Novel Herpes simplex viruses and vaccines based on such novel HSV-1 strains are described. In particular, viruses having a deletion in the terminal portion of R L are provided. The virus can be further modified to express heterologous antigens and also engineered to overproduce HSV Light particles. This is achieved by incorporating a is mutation into the UL26 gene.</p> |
| 申请公布号 |
CA2101639(C) |
申请公布日期 |
2003.06.03 |
| 申请号 |
CA19922101639 |
申请日期 |
1992.01.30 |
| 申请人 |
SMITHKLINE BEECHAM BIOLOGICALS S.A. |
发明人 |
BROWN, SUSANNE M.;MACLEAN, ALASDAIR R. |
| 分类号 |
A61K39/245;A61P31/12;A61P31/22;C12N7/00;C12N7/01;C12N7/04;C12N15/09;(IPC1-7):C12N7/01;A61K39/12;A61K39/295;C12N15/86 |
主分类号 |
A61K39/245 |
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