发明名称 2,2-DIPHENYLBUTANAMIDE DERIVATIVES AND MEDICINES CONTAINING THE SAME
摘要 2,2-Diphenylbutanamide derivatives represented by the following formula (1): <CHEM> Äwherein A represents -(CH2)n- (n is 1 or 2) or a methine (CH) group; when A is -CH2-, B represents a methine group or a nitrogen atom, with A and B forming a single bond; when A is -(CH2)2-, B represents a nitrogen atom, with A and B forming a single bond; when A is a methine group, B represents a quaternary carbon atom, with A and B forming a double bond; each of R<1> and R<2>, which are identical to or different from each other, represents a hydrogen atom, a lower alkyl group, or a cycloalkyl group, or R<1> and R<2> may form a heterocyclic ring together with the adjacent nitrogen atom; and Ar represents an optionally substituted phenyl group, bicyclic aromatic ring, monocyclic heterocyclic ring, bicyclic heterocyclic ring, or fluorene groupÜ; or salts of the derivatives. The derivatives or salts thereof exhibit excellent mu -opioid agonist activity and analgesic activity against neuropathic pain, and are useful as medicines such as peripheral analgesic drugs and neuropathic pain relieving drugs. <IMAGE>
申请公布号 KR20030043970(A) 申请公布日期 2003.06.02
申请号 KR20037004343 申请日期 2003.03.26
申请人 发明人
分类号 C07D401/04;A61P25/02;A61P29/00;C07D211/14;C07D211/18;C07D211/22;C07D211/70;C07D213/74;C07D215/38;C07D215/42;C07D217/22;C07D239/42;C07D241/20;C07D243/08;C07D277/42;C07D295/145;C07D295/185 主分类号 C07D401/04
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