ANTI-ADHESION MOLECULE ANTIBODY TO TREAT INFLAMMATION AND CANCER BY INDUCING THE IDIOTYPIC NETWORK

摘要

Disclosed are compositions for reducing an immune condition, such as inflammation or cancer, in an animal suffering from the immune condition or predisposed to suffer from the immune condition. The compositions comprise a binding agent that specifically binds to an adhesion molecules expressed on the surface of or released by a blood-borne cell or an endothelial cell lining a blood vessel, wherein the binding agent induces an immune response in the animal to the binding agent. Additional disclosed compositions comprise an agent that is capable of reducing inflammation and reducing cancer in an animal when administered to the animal in a therapeutically effective amount. Also disclosed are methods for administering such compositions to an animal suffering from or predisposed to suffer from the immune condition.