COMPOSITIONS AND METHODS FOR REVERSIBLY INDUCING CONTINUAL GROWTH IN NORMAL CELLS

摘要

A mutant modified cyclin dependent kinase protein, or biologically active fragment, derivative, homolog or analog thereof is provided, which reversibly induces continual growth in cultured cells when administered to the cells exogenously in culture. Methods of reversibly inducing continual growth in cultured cells, and methods of screening cancer-causing agents with the continual growth-induced cells, are also provided.