Cathecol hydrazone derivatives and pharmaceuticals thereof

摘要

A compound of formula I, where: R1 is C3-7cycloalkyl R2 is H, hydroxy, C1-5alkyl or ûCH2CH2C(=O)NH2 R3 and R4 and independently H, C1-7alkyl, -C(=X)-R5, or 2-, 3- or 4-pyridyl, pyrimidyl or phenyl substituted with one or two substituents selected from a group consisting of halogen, C1-6alkoxy, nitro, trifluoromethyl, C1-6alkyl and carboxyl, or R3 and R4 are directly bonded by C3-4 optionally containing oxygen, sulfur or nitrogen to form a heterocyclic ring. Also described is a pharmaceutical composition for inhibiting phosphodiesterase IV or TNF which comprises a pharmaceutically effective amount of the compound described above and a pharmaceutically acceptable carrier.