BIAROMATIC COMPOUNDS CONTAINING THE ADAMANTIL GROUP, PHARMACEUTIC AND COSMETIC COMPOSITIONS CONTAINING THEM AND THEIR APPLICATION

摘要

1-Phenyladamantane derivatives of formula (I) and their salts and isomers are new: R1 = Me, (CH2)nOR4, etc.; R2 = H, halogen, 1-20C alkyl, OR4 or OCH2OCH2CH2OMe; R3 = Y(CH2)pY(CH2)qR8, etc.; X = one of the following groups, which can be read in both directions: -CO-O-; -CO-S-; -CO-C IDENTICAL C-; -CHOH-C IDENTICAL C-, etc.; Ar = p-phenylene substituted by R9, pyridinediyl, 2,6-naphthylene substituted by R9, etc.; n = 0 or 1; p = 1-12; q = 0-12; t = 0-2; Y = O or SOt; R4 = H, lower alkyl or COR11; R8 = H, 1-20C branched alkyl, a 3-6C cycloaliphatic group, mono- or polyhydroxyalkyl (with OH groups optionally protected as methoxy, acetoxy or acetonide), etc.; R9 = H, halogen, 1-20C alkyl, OR4 or OCH2OCH2CH2OMe; R11 = lower alkyl with provisos.