发明名称 |
METHOD FOR THE FERMENTATIVE PRODUCTION OF PYRUVATE |
摘要 |
The invention relates to a method for the fermentative production of pyruvate. The chemical methods for producing pyruvate known in prior art are technically complex and cost-intensive. The disadvantage of known biological methods is that the substrates are not converted 100 % into pyruvate and the product yield therefore suffers. The inventive method enables pyruvate to be produced microbially with a near 100 % conversion of the substrate. Increased production of pyruvate can be achieved by using micro-organisms that have been genetically modified, i.e. by the deletion or reduced expressed of nucleotide sequences that code for the pyruvate-dehydrogenase complex, pyruvate decarboxylase, pyruvate ferredoxin-oxidoreductase, pyruvate flavodoxin-oxidoreductase, pyruvate formiate-lyase, phosphoenolpyruvate synthetase and/or for pyruvate oxidase. |
申请公布号 |
WO03000913(A3) |
申请公布日期 |
2003.05.30 |
申请号 |
WO2002DE02144 |
申请日期 |
2002.06.12 |
申请人 |
FORSCHUNGSZENTRUM JUELICH GMBH;BOTT, MICHAEL;GERHARZ, TANJA;TAKORS, RALF;ZELIC, BRUNO |
发明人 |
BOTT, MICHAEL;GERHARZ, TANJA;TAKORS, RALF;ZELIC, BRUNO |
分类号 |
C12N1/21;C12P7/40 |
主分类号 |
C12N1/21 |
代理机构 |
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