The present invention provides a method of identifying a modulator of a voltage gated sodium channel (VGSC), which method comprises bringing into contact a VGSC, a p11 peptide and a test compound under conditions where the VGSC and the p11 peptide are capable of forming a complex in the absence of the test compound; and measuring an activity of the VGSC, wherein a change in the activity of the VGSC relative to the activity in the absence of the test compound indicates that the test compound is a modulator of said VGSC. Compounds identified in such screening methods are proposed for use in the treatment of VGSC-related conditions, for example in the treatment or prevention of pain. Also provided are methods of enhancing the functional expression of a voltage gated sodium channel (VGSC) in a cell comprising the step of increasing the level of p11 in the cell.
申请公布号
WO03016917(A3)
申请公布日期
2003.05.30
申请号
WO2002GB03852
申请日期
2002.08.20
申请人
UNIVERSITY COLLEGE LONDON;OKUSE, KENJI;BAKER, MARK;POON, LOUISA;WOOD, JOHN, NICHOLAS;MALIK-HALL, MISBAH