Controlled release tolterodine formulation that releases not less than 80% of the active compound in under 18 hours

摘要

Described is a pharmaceutical formulation containing tolterodine or a tolterodine-related compound, or a pharmacologically acceptable salt thereof, as active ingredient, in which the formulation exhibits a controlled in vitro release of the active ingredient in a phosphate buffer at pH 6.8 of not less than about 80% after 18 hours, and after oral administration to a patient is capable of maintaining a substantially constant serum level of the active moiety or moieties for 24 hours. The use of the pharmaceutical formulation for treating overactive bladder, nocturia and gastrointestinal disorders is also described.