| 摘要 |
A multibinding compound of formula L-X-L (I) wherein: each L is independently a compound of formula (a), (b), (c), (d), (e), (f), (g) or (h) and X is Xa-Z-(Ya-Z)m-Yb-Z-Xa; m is 0 to 20; each Xa is independently -O-, -S-, -NR-, -C(O)-, -C(O)O-, -C(O)NR-, -C(S)-, -C(S)O-, -C(S)NR- or a covalent bond; each Z is independently optionally substituted alkylene, cycloalkylene, alkenylene, alkynylene, cycloalkenylene or arylene, heteroarylene, heterocyclene, or a covalent bond; Ya and Yb are independently -O-, -C(O)-, -OC(O)-, -C(O)O-, -NR-, -S(O)n-, -C(O)NR'-, -NR'C(O)-, -NR'C(O)NR'-, -NR'C(S)NR'-, -C(=NR')-NR'-, -NR'-C(=NR')-, -OC(O)-NR'-, -NR'-C(O)-O-, -N=C(Xa)-NR'-, -NR'-C(Xa)=N-, -P(O)(OR')-O-, -O-P(O)(OR')-, S(O)nCR'R"-, -S(O)n-NR'-, -NR'-S(O)n-, -S-S- or a covalent bond; A is an aryl or a heteroaryl ring; B is a heterocycloamino group, which optionally attaches X to L; C is an aryl or heteroaryl ring, which optionally attaches the ligand to a linker; GÆ is pyrrolidine, piperidine or a group of formula (2) which optionally attaches L to X; G is aryl, heteroaryl heterocyclic or cycloalkyl, which optionally attaches L to X P is aryl or heteroaryl ring which optionally attaches L to X; S is heterocycloamino which optionally attaches L to X; R20 and R21 are independently hydrogen, alkyl or a covalent bond attaching L to X or together with the nitrogen atom to which they are attached form a heterocycloamino ring, which optionally attaches L to X; R25 and R26 are independently hydrogen, alkyl, aralkyl, or a covalent bond attaching L to X or together with the nitrogen atom to which they are attached form a heterocycloamino group, which optionally attaches L to X; D" is alkylene; D is NR31R32, -N+(R33R34R35) or -OR32; F is -NR40-, -O-, -S- or ûCHR41-; F" is a covalent bond, -OR43, -NR42R43 or -N+R43R44R45 and the rest of the variables are as defined in the specification. The compounds are useful for treating a disease mediated by muscarinic receptor such as chronic obstructive pulmonary disease, chronic bronchitis, irritable bowel syndrome or urinary incontinence.
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