| 发明名称 |
METHOD FOR IDENTIFICATION OF TUMOR TARGETING ENZYMES |
| 摘要 |
The present invention relates to a method for identification of enzymes that are preferentially expressed in certain tumor tissue as compared with rapidl y growing normal cells or tissue, use of said enzymes for the compound design to generate an active anticancer substance selectively in tumor tissue, compoun ds designed based on said enzymes, their pharmaceutically acceptable salts as well as pharmaceutical composition thereof. |
| 申请公布号 |
CA2468170(A1) |
申请公布日期 |
2003.05.30 |
| 申请号 |
CA20022468170 |
申请日期 |
2002.11.18 |
| 申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
OKABE, HISAFUMI;SHIMMA, NOBUO;TSUKUDA, TAKUO;UMEDA, ISAO;ISHITSUKA, HIDEO |
| 分类号 |
G01N33/50;A61K31/337;A61K31/401;A61K31/426;A61K31/4725;A61K31/4745;A61K31/506;A61K31/517;A61K31/519;A61K31/53;A61K31/5377;A61K31/704;A61K31/7068;A61K31/7076;A61K38/00;A61K47/48;A61P35/00;A61P43/00;C07K5/06;C07K7/06;C12N15/09;C12Q1/02;C12Q1/26;C12Q1/32;C12Q1/37;C12Q1/48;C12Q1/68;G01N33/15;G01N33/573;G01N33/574;G01N37/00 |
主分类号 |
G01N33/50 |
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