| 摘要 |
<p>The compounds of the invention, hydrophilic (S)-amlodipine salts or their hydrates and pharmaceutical compositions, are useful for the treatment of hypertension and angina. The molecular formula of the salt hydrates is C20H25N2O5C1 • n1X • n2H2O, in which, X=organic acids, such as benzene sulfonic acid, aspartic acid, acetic acid, tartaric acid; inorganic acids, such as sulfuric acid and hydrobromic acid; monatomic acid n1=1, biatomic acid, n1=0.5; n2=0, 1, 2. Hydrophilic (S)-amlodipine salts or their hydrates, with a very high bioavailability, can be made into pharmaceutical compositions.</p> |
