发明名称 |
NOVEL TETRONIC ACID DERIVATIVE |
摘要 |
Using the expression of a molecular chaperone GRP78 as an indication, attempts have been made to search for a substance capable of controlling the expression of GRP78. As a result, versipelostatin (also called JL68) represented by the formula (I), which is a novel tetronic acid derivative having an activity of inhibiting the GRP78 expression, is isolated from a metabolite of Streptomyces versipellis 4083-SVS6 strain. This versipelostatin can be obtained by culturing the Streptomyces versipellis 4083-SVS6 strain and collecting from the culture supernatant.
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申请公布号 |
WO03044209(A1) |
申请公布日期 |
2003.05.30 |
申请号 |
WO2002JP12237 |
申请日期 |
2002.11.22 |
申请人 |
SHINYA, KAZUO;TSURUO, TAKASHI;TOMIDA, AKIHIRO;PARK, HAE-RYONG |
发明人 |
SHINYA, KAZUO;TSURUO, TAKASHI;TOMIDA, AKIHIRO;PARK, HAE-RYONG |
分类号 |
A61K31/7048;A61P35/00;A61P43/00;C07H17/08;C12P19/62;(IPC1-7):C12P19/62;A61K31/704;A61K35/74 |
主分类号 |
A61K31/7048 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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