Anti-viral pyrimidine derivatives

摘要

Pyrimidine-based derivative compounds of formula (I) and compositions thereof that are useful for the treatment of viral infections, particularly human cytomegalovirus infection are disclosed, wherein: X is -NR3R4; Y is -N(R6)-; R1 is a member selected from the group consisting of -NO2, -C(O)R9, -CO2R10 , -C(O)NR7R8-, -S(O)m NR7R8 and ûCN; R2 is a member selected from the group consisting of hydrogen, alkyl, -O-alkyl, -S-alkyl, halogen and cyano; R3 and R4 are taken together with the nitrogen atom to which each is attached form a 5-membered ring containing from one to three heteroatoms in the ring; R5 is a member selected from the group consisting alkyl, aryl and arylalkyl; R6 is a member selected from the group consisting of hydrogen, alkyl, aryl and arylalkyl; or is combined with R5 and the nitrogen atom to which R5 and R6 are attached to form a 5-, 6-, 7-or 8-membered ring; R7 and R8 are members independently selected from the group consisting of hydrogen and alkyl; R9 and R10 are members independently selected from the group consisting of hydrogen, alkyl, aryl and arylalkyl; m is an integer of from 1 to 2; and the compound of formula (I) having a molecular weight of from about 150 to about 750, with the proviso that when -Y-R5 is other than an imidazole ring.