HISTIDINE PROLINE RICH GLYCOPROTEIN (HPRG) AS AN ANTI-ANGIOGENIC AND ANTI-TUMOR AGENT
摘要
Histidine Proline Rich Glycoprotein (HPRG) polypeptides or fragments thereof including pentapeptide fragments and multimers thereof, and other biologically active derivatives of HPRG are anti-angiogenic. These compounds may be used to inhibit angiogenesis or treat a disease or condition in which angiogenesis is pathogenic. These compounds therefore have anti-tumor activity and are used in methods for inhibiting the growth of primary tumors or metastases. Antibodies specific for epitopes of the His-Pro rich domain of HPRG are stimulators of angiogenesis and are useful for promoting neovascularization in pertinent disease states.
申请公布号
WO02064621(A3)
申请公布日期
2003.05.30
申请号
WO2002US04336
申请日期
2002.02.14
申请人
ATTENUON, LLC;DONATE, FERNANDO;HARRIS, SCOTT;PLUNKETT, MARIAN, L.;MAZAR, ANDREW, P.
发明人
DONATE, FERNANDO;HARRIS, SCOTT;PLUNKETT, MARIAN, L.;MAZAR, ANDREW, P.