发明名称 |
Human-derived bradeion proteins, DNA coding for the proteins, and uses thereof |
摘要 |
A human-derived bradeion protein, which has the following properties: (i) it is a transmembranous protein; (ii) it has a structure characteristic of growth hormone and cytokine receptors even in a structure of its transmembranous portion when its structure is determined by a hydrophobicity analysis according to Kyte-Doolittle method; (iii) it is expressed at a high level in a human adult brain, and in less amount in the heart, while it is not expressed in other adult organs or fetus; (iv) it induces programmed cell death (apoptosis) when over-expressed in a cultured human nerve cell lines; (v) it induces termination of cell division and aging when over-expressed in a cultured human normal cell; (vi) it is located in cytoplasm, and forms an intracellular aggregate when overexpressed; and (vii) besides human adult neurons, it is specifically expressed in a human colorectal cancer cell line or in a skin cancer cell line, or an analogue thereof.
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申请公布号 |
US2003099970(A1) |
申请公布日期 |
2003.05.29 |
申请号 |
US20020190555 |
申请日期 |
2002.07.09 |
申请人 |
SECRETARY OF AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY |
发明人 |
TANAKA MANAMI;TANAKA TOMOO |
分类号 |
C12N15/09;C07K14/47;C07K14/71;C07K14/715;C07K16/28;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/00;C12P21/02;C12P21/08;C12Q1/68;C12R1/91;G01N33/53;G01N33/566;G01N33/574;G01N33/577;(IPC1-7):C12Q1/68;C07H21/04;C12N5/06;C07K14/705;C07K16/30 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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