| 摘要 |
The invention provides isolated nucleic acids that encode human NAC-1, and fragments thereof, vectors for propagating and expressing human NAC-1 nucleic acids, host cells comprising the nucleic acids and vectors of the present invention, proteins, protein fragments, and protein fusions of the novel human NAC-1 isoforms, and antibodies thereto. The invention further provides transgenic cells and non-human organisms comprising human NAC-1 nucleic acids, and transgenic cells and non-human organisms with targeted disruption of the endogenous orthologue of the human NAC-1 gene. The invention further provides pharmaceutical formulations of the nucleic acids, proteins, and antibodies of the present invention, and diagnostic, investigational, and therapeutic methods based on the human NAC-1 nucleic acids, proteins, and antibodies of the present invention.
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