发明名称 |
Oral dosage form of a sulfonamide prodrug |
摘要 |
A pharmaceutical composition that is substantially free of water comprises at least one orally deliverable dosage unit comprising a therapeutically effective amount of a sulfonamide prodrug and, where the prodrug is readily degradable ex vivo, has means to inhibit such degradation prior to oral administration. Illustratively the prodrug is parecoxib or a water-soluble salt thereof, and the composition has means to inhibit conversion of the parecoxib to valdecoxib. A method of treating or preventing a COX-2 mediated disorder in a subject comprises (a) dissolving at least one dosage unit of such a composition in a pharmaceutically acceptable aqueous vehicle to form a solution, and (b) orally administering the solution to the subject before substantial precipitation of insoluble matter occurs in the solution.
|
申请公布号 |
US2003100595(A1) |
申请公布日期 |
2003.05.29 |
申请号 |
US20020292682 |
申请日期 |
2002.11.12 |
申请人 |
KARIM AZIZ;NEMA SANDEEP;EWING GARY D. |
发明人 |
KARIM AZIZ;NEMA SANDEEP;EWING GARY D. |
分类号 |
A61K47/48;A61K9/08;A61K9/14;A61K9/19;A61K9/20;A61K31/365;A61K31/415;A61K31/42;A61K47/10;A61K47/20;A61K47/22;A61K47/26;A61K47/46;A61P29/00;A61P43/00;(IPC1-7):A61K31/415 |
主分类号 |
A61K47/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|