发明名称 |
Detection of DNA hybridization on surfaces |
摘要 |
A DNA hybridization surface includes a support having a self assembled monolayer on a metallized surface. The self assembled monolayer includes an alkanethiol and a strand of nucleic acids comprising a functional group that binds to the metallized surface. A method for detecting DNA hybridization in a sample includes (a) incubating a DNA hybridization surface with an aqueous sample that includes a fragment of DNA to produce an incubated DNA hybridization surface; (b) rinsing the incubated DNA hybridization surface to produce a rinsed incubated DNA hybridization surface; (c) contacting the rinsed incubated DNA hybridization surface with a liquid crystal; and (d) determining whether the liquid crystal is uniformly anchored on the rinsed incubated DNA hybridization surface.
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申请公布号 |
US2003099993(A1) |
申请公布日期 |
2003.05.29 |
申请号 |
US20020262562 |
申请日期 |
2002.10.01 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
ABBOTT NICHOLAS L.;BRAKE JEFFREY M.;BHINDER PRITIPAL S. |
分类号 |
B01J19/00;B05D3/00;C12M1/34;C12Q1/68;C40B40/06;C40B50/14;C40B60/14;(IPC1-7):C12Q1/68 |
主分类号 |
B01J19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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