New ureido-substituted pyrrolidine-dione derivatives, useful in human or veterinary medicine as broad-spectrum antibacterial agents

摘要

Ureido-substituted pyrrolidine-dione derivatives (I) are new. Urea derivatives of formula (I) and their salts, solvates and hydrates are new; R<1>, R<11> = H, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclyl, R<1> being optionally substituted by 1-3 groups R<12>; NR<1>R<11> = heterocycle; R<12> = halo, CF3, OCF3, NO2, NH2, mono- or dialkylamino, cycloalkyl, aryl, heteroaryl, heterocyclyl, OH, alkoxy, COOH, alkoxycarbonyl, CONH2, mono- or dialkylaminocarbonyl, SO2NH2, mono- or dialkylaminosulfonyl, arylaminosulfonyl, heterocyclylaminosulfonyl, heteroarylaminosulfonyl, NHCONH2, NHCOOH or alkoxycarbonylamino (where aryl and heteroaryl groups are optionally substituted by 1 or 2 of halo, OH, alkoxy, CF3, OCF3, NO2, NH2, CN or mono- or dialkylamino); R<2> = H or Me; R<3>, R<4> = H or 1-3C alkyl; R<5> = halo, CF3, OCF3, NO2, NH2, mono- or dialkylamino, OH, alkoxy, COOH, alkoxycarbonyl, CONH2 or mono- or dialkylaminocarbonyl; n = 0-3. An Independent claim is also included for the preparation of (I).