发明名称 |
PEPTIDE NUCLEIC ACIDS HAVING ENHANCED BINDING AFFINITY, SEQUENCE SPECIFICITY AND SOLUBILITY |
摘要 |
A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone, and contain C1-C8 alkylamine side chains. Methods of enhancing the solubility, binding affinity and sequence specificity of PNAs are provided. |
申请公布号 |
EP0960121(A4) |
申请公布日期 |
2003.05.28 |
申请号 |
EP19970935053 |
申请日期 |
1997.07.24 |
申请人 |
BUCHARDT, DORTE;NIELSEN, PETER EIGIL, PROF. DR.;EGHOLM, MICHAEL;BERG, ROLF |
发明人 |
NIELSEN, PETER, E.;EGHOLM, MICHAEL;BERG, ROLF, H.;BUCHARDT, OLE |
分类号 |
C12N15/09;A61K31/70;A61K31/7088;A61K48/00;C07D233/64;C07H21/00;C07K5/02;C07K5/078;C07K14/00;C08G69/00;C08G69/08;C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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