QUINAZOLINONE DERIVATIVES

摘要

A compound given by general formula (1): Äwherein T represents oxygen or sulfur atom, Y represents alkyl, cycloalkyl group, etc., ring W represents benzene ring, etc., R<1> and R<2> represent independently hydrogen atom, lower alkyl group, etc., and R<3> represents hydrogen atom, alkyl group, etc. Z represents a group given by formula: äwherein A<1> and A<2> represent independently hydrogen atom, alkyl group, etc. and G represents straight chain alkylene having 1-6 of the carbon number, etc.ü or a group given by formula: äwherein n represents 0, 1 or 2, ring E represents 4-8 membered saturated heterocyclic ring containing nitrogen atom(s), and A<3> represents hydrogen atom, alkyl group, etc.üÜ, its prodrug or pharmaceutically acceptable salt thereof is an antagonist against muscarinic receptor that is useful as anticholinergic medicaments, and therefore it is useful as pollakiuria or urinary incontinence remedy.